Preheat air fryer to 335°. In a small bowl, combine beef, ketchup, mustard and salt, mixing lightly but thoroughly. Cut onion into 1/2-in. slices; separate into rings. Fill 8 slices with half of the beef mixture (save remaining onion rings for another use). Top each with a piece of cheese and remaining beef mixture.
In a shallow bowl, mix flour and garlic powder. Place bread crumbs and eggs in separate shallow bowls. Dip filled onion rings in flour to coat both sides; shake off excess. Dip in egg, then in bread crumbs, patting to help coating adhere.
In batches, place onion rings in a single layer in greased air-fryer basket; spritz with cooking spray. Cook until golden brown and a thermometer inserted into beef reads 160°, 12-15 minutes. If desired, serve with spicy ketchup.